Vascular Biology Laboratory

The Vascular Biology Laboratory (VBL) focuses on the interactive effects of aging and exercise training on skeletal muscle vascular beds.  The lab’s mission is to understand how the structure and function of arteries change with age and how these changes increase cardiovascular disease risk in the elderly.  In addition, we are determining mechanisms by which exercise training attenuates, or reverses, the detrimental effects of aging on vascular function.
Functional studies are conducted using isolated perfused arteries to determine the cell signaling events in endothelial and vascular smooth muscle cells that mediate endothelium-dependent vasodilation. Biochemical and molecular techniques are used to determine mechanisms contributing to age-induced endothelial dysfunction and to determine mechanisms by which exercise training improves vascular cell function in senescent arteries.